Oy, My Genes! is Practical Jewish Genetic Analysis.

Now free!

Logo

Members of the Ashkenazi Jewish community have an increased risk of some inherited conditions. Fortunately, research has identified genetic factors that indicate carrier status for Tay-Sachs Disease, Gaucher Disease, and other inherited conditions.

This well-established research is the foundation of the Oy, My Genes! analysis. For FREE, Oy, My Genes! will analyze your 23andMe raw data for possible carrier status of:

  • Crohn's disease
  • Cystic fibrosis
  • Factor XI deficiency
  • Fanconi anemia
  • Gaucher disease
  • Maple Syrup Urine Disease
  • Mucolipidosis type IV
  • Niemann-Pick disease
  • Tay-Sachs Disease
  • Torsion Dystonia

Analyze your data now

Oy My Genes Example

Oy, My Genes! is not a substitute for genetic counseling. The information and analysis on this site have not been evaluated by the FDA. Your analysis is not intended to diagnose, mitigate, treat, cure, or prevent any disease or health condition.

Science

The GenomeSource: Genome.gov

Your Genome and Personalized Genomics

Your genome is the instruction manual for you. 23andMe analyzes the regions of the human genome which are known to vary between people. It is actually a subset of the billions of possible instructions in your genome.

SNP Genotyping

Scientists call a variation at a specific location a single-nucleotide polymorphism (SNP). Your SNP genotype is the instruction you have at that specific location. Your SNP genotype, if it is on a non-sex chromosome, is made up of two alleles, one that you have inherited from each parent.

Your 23andMe raw data reports your genotype for thousands of SNPs. This genotype may be part of a larger sequence that encodes for a protein, and its genotype may impact that protein. Oy, My Genes! will analyze your genotype for about 20 SNPs.

Our Analysis

Analyze your data now

Analogy

Imagine that you have an instruction manual for you- your genome. Oy, My Genes! will go to specific words in your instructions and look for typos. Sometimes these typos are harmless, and other times these typos put your body at risk of making something incorrectly.

Is my genotype a guarantee of risk?

No. Oy, My Genes! can only analyze your genotype for the alleles that research has correlated most strongly with risk of a given condition. However:

  • there are environmental factors that may alter your risk
  • other genes interacting with a target gene may also change your risk
  • your genotype may not have been interpreted correctly (it may represent a false negative or false positive)
  • genes may not even be on or active, and can be under the control of an external factor
  • one of your alleles may be damaged, impacting its ability to provide useful instructions

You must speak to a genetic counselor for a true analysis of your risk for a given condition.

How does the analysis work?

You will log in using your 23andMe account. Oy, My Genes! won't be able to see your raw data, but will ask 23andMe for data to analyze on your behalf. With information on the data at each of your SNPs, Oy, My Genes! will compare your genotype - the actual code in your genome - against the risk allele. If you have one copy of the risk allele, you may be a carrier for a given condition. You are at increased risk of a condition if both of your copies of the allele match the risk allele.

Some risk alleles are't alleles at all and may actually represent a deletion. This means that the instructions that would normally appear at a given position are not there.

  1. Connect with 23andMe.

  2. Log in

  3. Provide consent

  4. Analyze

Analyze your data now

Oy, My Genes! is not a substitute for genetic counseling. The information and analysis on this site have not been evaluated by the FDA. Your analysis is not intended to diagnose, mitigate, treat, cure, or prevent any disease or health condition.

About Oy, My Genes!

Corinne Pascale and Zach Stroum bring you Oy, My Genes!

Corinne first entered the world of personalized genomics while attending a course on Jewish genetics at the University of Washington Hillel. As a young Jewish couple planning their wedding, Corinne and Zach worried about the health of their future children. They had heard that Tay-Sachs and Gaucher Disease were more common in the Jewish community, but were unsure of what these diseases were and how they might be carriers.

Corinne, who holds degrees in Biomedical/Electrical Engineering (BS, Washington University in St. Louis) and Engineering Management (MS, Carnegie Mellon University), first built a spreadsheet to analyze her raw 23andMe data. Upon realizing that this could be made programmatic and available to the whole community, she teamed up with her fiance to build something for everyone.

Zach brought his graphic design skills along with his experience in customer service management (BS, Anthropology, University of Washington). It was his exclamation that led to the company's name - "Oy, my Genes!"

Contact